A 7 year old unimmunized girl is brought to the clinic with fever, sore throat, and neck swelling. Examination shows cervical lymphadenopathy and a thick gray pharyngeal pseudomembrane that bleeds when removed. She later develops palpitations and elevated troponin levels. Which of the following best describes the molecular action of the toxin responsible for this disease?

1. A)Inactivation of elongation factor 2 by ADP ribosylationGABARITO
2. B)Cleavage of 28S ribosomal RNA
3. C)Activation of guanylate cyclase in intestinal epithelial cells
4. D)Proteolytic activation of adenylate cyclase in host macrophages
5. E)Inhibition of peptidoglycan cross linking