A 6 year old boy is brought to clinic because of fatigue, gum bleeding, and pain in both legs. His family recently experienced food insecurity, and his diet has consisted mainly of crackers and processed snacks. Examination shows perifollicular hemorrhages and swollen gums. Defective activity of which of the following enzymes is most directly responsible for this patient's symptoms?
- A)Dihydrofolate reductase
- B)Prolyl and lysyl hydroxylaseGABARITO
- C)Lysyl oxidase
- D)Homogentisate oxidase
- E)Branched chain alpha ketoacid dehydrogenase
Explicação
This child has scurvy due to vitamin C deficiency. Ascorbic acid is required for hydroxylation of proline and lysine residues during collagen synthesis, and defective collagen leads to gingival bleeding, perifollicular hemorrhage, and bone pain. The malnutriti... Ver explicação completa e trilha adaptativa →