A 3 month old boy is brought to clinic for poor feeding, weak cry, constipation, and progressive lethargy. His parents recently began giving him small amounts of honey for cough. Examination shows hypotonia, ptosis, and decreased deep tendon reflexes. Which of the following is the best explanation for this patient’s illness?
- A)Toxin mediated inhibition of glycine release
- B)Mutation causing survival motor neuron deficiency
- C)Immune mediated demyelination of peripheral nerves
- D)Toxin mediated inhibition of acetylcholine release from presynaptic terminalsGABARITO
- E)Autoantibodies to postsynaptic acetylcholine receptors
Explicação
Toxin mediated inhibition of acetylcholine release from presynaptic terminals is correct. Infant botulism results from ingestion of spores that germinate in the gut and produce toxin, leading to descending flaccid paralysis. Honey exposure, constipation, hypot... Ver explicação completa e trilha adaptativa →