A 23-year-old man with chronic sinusitis, recurrent childhood otitis media, and infertility presents with a chronic productive cough and progressive dyspnea. Vital signs: BP 118/76, HR 102, RR 22, SpO2 88% on room air. Cardiac examination reveals PMI at the right midclavicular line. Chest X-ray shows dextrocardia. Sputum culture is negative for bacterial infection. He denies recent cocaine use. Which diagnosis best explains his clinical presentation?
- A)Kartagener syndromeGABARITO
- B)Persistent pulmonary hypertension of the newborn
- C)Patent foramen ovale
- D)Transposition of the great arteries
- E)Endocardial cushion defect
Explicação
Kartagener syndrome is correct. Dextrocardia in the setting of recurrent sinopulmonary infections and infertility indicates primary ciliary dyskinesia due to dynein arm defects. Abnormal ciliary function during embryogenesis disrupts left right body asymmetry ... Ver explicação completa e trilha adaptativa →