A 44-year-old man presents with acute bacterial cellulitis of the left lower leg. Vital signs show BP 138/82 mmHg, HR 98/min, RR 16/min, temperature 38.2°C, and SpO2 98% on room air. Physical examination reveals erythema, warmth, and edema without fluctuance. WBC count is elevated at 14,200/μL with left shift. Tissue biopsy obtained early in the infection demonstrates dense neutrophilic infiltrate actively migrating toward the bacterial focus. Which complement product primarily mediates neutrophil chemotaxis in this acute inflammatory response?
- A)C3b
- B)Membrane attack complex
- C)C1 esterase inhibitor
- D)Factor H
- E)C5aGABARITO
Explicação
C5a is a powerful chemotactic factor for neutrophils and also increases vascular permeability and leukocyte activation. It helps recruit neutrophils to sites of acute bacterial infection. Ver explicação completa e trilha adaptativa →