A 16-year-old girl presents with primary amenorrhea and is found to have absent uterus and fallopian tubes on pelvic ultrasound, but normal ovarian function with appropriate secondary sexual characteristics. Her kidney ultrasound reveals unilateral renal agenesis. Genetic testing shows a normal 46, XX karyotype. Which of the following embryologic defect best explains this constellation of findings?
- A)Abnormal development of the mesonephric (Wolffian) duct
- B)Persistence of the mesonephric (Wolffian) duct in a female
- C)Failure of the paramesonephric (Müllerian) duct to developGABARITO
- D)Incomplete fusion of the urogenital and anal portions of the cloaca
- E)Failure of germ cells to migrate from the yolk sac
Explicação
Müllerian agenesis (Mayer-Rokitansky-Küster-Hauser syndrome) results from failure of the paramesonephric (Müllerian) ducts to develop. These ducts normally give rise to the fallopian tubes, uterus, and upper vagina in females. Because ovaries develop from the ... Ver explicação completa e trilha adaptativa →