A 25-year-old man is brought to the emergency department by his partner approximately 2 hours after intentionally ingesting an unknown quantity of aspirin tablets. His partner reports he consumed most of a large bottle during a heated argument. On arrival, his temperature is 38.2°C, blood pressure is 118/74 mmHg, heart rate is 108 bpm, and respiratory rate is 28 breaths per minute. He complains of ringing in his ears and appears diaphoretic and agitated. Arterial blood gas reveals a primary respiratory alkalosis with a concurrent metabolic acidosis. Serial serum salicylate levels are obtained every hour and demonstrate that the drug concentration falls by the same absolute amount each hour rather than by the same percentage. Which of the following best describes this elimination pattern?
- A)Distribution phase metabolism
- B)First order kinetics
- C)Saturable zero order kineticsGABARITO
- D)Enterohepatic recirculation
- E)Competitive antagonism
Explicação
Aspirin at high doses is a classic drug that can display zero order kinetics, in which a constant amount of drug is eliminated per unit time because metabolic pathways are saturated. The clue is the same absolute amount, not the same proportion, being removed ... Ver explicação completa e trilha adaptativa →