A 73-year-old hospitalized man with community-acquired pneumonia is treated with IV ceftriaxone. Two weeks into therapy, he develops watery diarrhea, cramping abdominal pain, and fever (38.5°C). Vital signs show HR 102/min, BP 128/82 mmHg, RR 18/min. Stool testing is positive for Clostridioides difficile toxin. WBC is elevated at 14,500/μL. He denies recent antibiotic use prior to ceftriaxone. Which of the following most likely predisposed him to this complication?
- A)Blockade of viral DNA polymerase
- B)Inhibition of fungal ergosterol synthesis
- C)Direct stimulation of colonic muscarinic receptors
- D)Irreversible inhibition of bacterial topoisomerase II
- E)Disruption of normal gut flora by a broad spectrum beta-lactam antibioticGABARITO
Explicação
Broad spectrum antibiotics such as cephalosporins can disrupt normal intestinal microbiota, allowing overgrowth of Clostridioides difficile and toxin mediated colitis. The timing after hospitalization and ceftriaxone exposure is classic. The pathogenic issue i... Ver explicação completa e trilha adaptativa →