A 55-year-old man with end-stage renal disease on hemodialysis three times weekly presents with BP 148/92, HR 88, RR 16, temp 37°C, and SpO2 98%. Laboratory studies reveal persistently elevated PTH (156 pg/mL), serum phosphate 6.2 mg/dL, and serum calcium 8.1 mg/dL despite dietary phosphate restriction and active vitamin D supplementation. Physical examination reveals mild periarticular soft tissue deposits at the shoulders bilaterally. Chest X-ray shows no pulmonary edema. He denies bone pain. His physician prescribes a medication that sensitizes calcium-sensing receptors on parathyroid cells to suppress PTH secretion. Which drug was most likely prescribed?
- A)Teriparatide
- B)Calcitonin
- C)CinacalcetGABARITO
- D)Alendronate
- E)Sevelamer
Explicação
Cinacalcet is a calcimimetic that increases sensitivity of the calcium sensing receptor on parathyroid cells, thereby suppressing PTH release. It is especially useful in secondary hyperparathyroidism in patients with chronic kidney disease on dialysis. Ver explicação completa e trilha adaptativa →