A 55-year-old woman with type 2 diabetes and hypertension presents with fatigue. Vital signs: BP 142/88 mmHg, HR 88/min, RR 16/min, temp 37°C, SpO2 98% on room air. Lipid panel shows total cholesterol 240 mg/dL, LDL 130 mg/dL, HDL 35 mg/dL, triglycerides 350 mg/dL. HbA1c is 7.8%. She denies chest pain or dyspnea. Atorvastatin is initiated. Which mechanism best explains this drug's therapeutic effect on her lipid abnormalities?
- A)Inhibition of cholesterol esterification in the endoplasmic reticulum
- B)Inhibition of hepatic HMG-CoA reductase increases LDL receptor expressionGABARITO
- C)Inhibition of PCSK9 protease activity
- D)Activation of lipoprotein lipase in peripheral tissues
- E)Direct inhibition of apolipoprotein B-100 synthesis
Explicação
Statins inhibit HMG-CoA reductase, reducing intracellular cholesterol. This triggers increased expression of LDL receptors on hepatocytes, enhancing clearance of LDL particles and lowering serum LDL cholesterol. This is the primary mechanism of statin efficacy... Ver explicação completa e trilha adaptativa →