A 67-year-old man with severe COPD presents with vomiting, tremor, and palpitations. Vital signs show HR 128/min, BP 148/92, RR 22/min, temperature 37.2°C, and SpO2 92% on home oxygen. He denies recent respiratory infections. Serum theophylline level is 24 mcg/mL (therapeutic range 10-20). He has taken an older bronchodilator for years. Electrocardiogram shows new supraventricular tachycardia. Which medication is most likely responsible for his acute presentation?
- A)Tiotropium
- B)Montelukast
- C)TheophyllineGABARITO
- D)Ipratropium
- E)Omalizumab
Explicação
Theophylline has a narrow therapeutic index and toxicity causes nausea, tremor, and tachyarrhythmias, with seizures in severe cases. It is a methylxanthine bronchodilator and board questions often emphasize its adverse effect profile. Ver explicação completa e trilha adaptativa →