A 54-year-old woman with lymphoma receiving high-dose cyclophosphamide presents with dysuria and gross hematuria. Vital signs show BP 128/82, HR 92, RR 18, Temp 37.2°C, SpO2 98% on room air. Urinalysis reveals 50 RBCs/hpf and blood 3+ with negative nitrites and leukocyte esterase. Cystoscopy demonstrates hemorrhagic cystitis. She denies fever or flank pain. Which medication reduces this chemotherapy-induced bladder toxicity when given prophylactically?
- A)Amifostine
- B)MesnaGABARITO
- C)Filgrastim
- D)Dexrazoxane
- E)Leucovorin
Explicação
Cyclophosphamide and ifosfamide produce the toxic metabolite acrolein, which can cause hemorrhagic cystitis. Mesna binds acrolein in the urine and protects the bladder. Ver explicação completa e trilha adaptativa →