A 24-year-old woman presents with a 3-month history of chronic diarrhea, bloating, and fatigue. She reports a pruritic blistering rash on extensor surfaces of her elbows. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.2°C, SpO2 98%. Laboratory studies reveal hemoglobin 9.8 g/dL with iron deficiency anemia; tissue transglutaminase (tTG) IgA elevated. Small-bowel biopsy shows villous atrophy, crypt hyperplasia, and increased intraepithelial lymphocytes. Abdominal pain is absent. Which antibody is most likely positive?
- A)Anti-mitochondrial antibody
- B)IgA anti-tissue transglutaminaseGABARITO
- C)Anti-smooth muscle antibody
- D)ASCA
- E)p-ANCA
Explicação
Celiac disease is an immune-mediated enteropathy triggered by gliadin in genetically susceptible patients and is associated with dermatitis herpetiformis and iron deficiency anemia. IgA anti-tissue transglutaminase is a high yield screening antibody, and biops... Ver explicação completa e trilha adaptativa →