A 63-year-old woman presents with progressive painless generalized lymphadenopathy over 6 months. Vital signs: BP 128/82, HR 88, RR 16, Temp 37.2°C, SpO2 98%. She denies night sweats. Laboratory evaluation shows hemoglobin 12.8 g/dL; lymph node biopsy demonstrates nodular proliferation of centrocytes and centroblasts. Cytogenetic analysis reveals t(14;18) translocation. Which of the following is the most likely consequence of this chromosomal abnormality?
- A)Overexpression of cyclin D1 due to immunoglobulin heavy chain promoter
- B)Constitutive activation of c MYC driving proliferation
- C)Formation of a fusion tyrosine kinase
- D)Constitutive activation of BCL2 preventing apoptosisGABARITO
- E)Loss of p53 mediated DNA repair
Explicação
Constitutive activation of BCL2 preventing apoptosis is correct. Follicular lymphoma is an indolent B cell lymphoma driven by t(14;18), which places BCL2 under the control of the immunoglobulin heavy chain promoter. The malignant cells survive abnormally rathe... Ver explicação completa e trilha adaptativa →