A 63-year-old woman with type 2 diabetes is started on a drug that binds the nuclear receptor PPAR gamma to improve insulin sensitivity. Three months later she reports lower extremity edema and weight gain, and her heart failure symptoms have worsened. Which of the following medications most likely caused this complication?
- A)Glipizide
- B)Exenatide
- C)PioglitazoneGABARITO
- D)Empagliflozin
- E)Metformin
Explicação
Thiazolidinediones such as pioglitazone activate PPAR gamma and can cause fluid retention worsening heart failure. Ver explicação completa e trilha adaptativa →