A 56-year-old man with type 2 diabetes mellitus presents to the emergency department with a 3-day history of severe facial pain, right-sided nasal congestion, and fever. On examination, he has significant edema of the right cheek and palate with black, necrotic tissue on the hard palate. Temperature is 39.4°C, blood pressure 148/92, heart rate 112, respiratory rate 22. CT of the paranasal sinuses shows opacification of the maxillary and ethmoid sinuses with erosion of the alveolar bone. A biopsy of the palatal tissue reveals broad, non-septate hyphae with acute-angle branching patterns. Which of the following is the most appropriate initial management?

1. A)Initiate high-dose IV fluconazole and optimize glycemic control
2. B)Perform immediate surgical debridement combined with IV amphotericin BGABARITO
3. C)Start broad-spectrum antibiotics and arrange outpatient imaging follow-up
4. D)Begin oral posaconazole monotherapy with endoscopic sinus evaluation
5. E)Apply topical antifungal agents and control blood glucose with insulin