A 6-year-old girl presents with early pubic hair development and accelerated linear growth. Vital signs reveal BP 145/92 mmHg, HR 88 bpm, RR 18, temp 37°C, SpO2 98%. Laboratory studies show serum cortisol 3 µg/dL (low), plasma renin activity <0.3 ng/mL/hr (low), serum potassium 2.8 mEq/L, and elevated 17-hydroxyprogesterone. No hirsutism is noted. Which of the following is the most likely diagnosis?

  1. A)Pheochromocytoma
  2. B)11-beta hydroxylase deficiencyGABARITO
  3. C)21-hydroxylase deficiency
  4. D)17-alpha hydroxylase deficiency
  5. E)Primary hyperaldosteronism

Explicação

11-beta hydroxylase deficiency causes androgen excess with hypertension and hypokalemia from 11-deoxycorticosterone accumulation. Ver explicação completa e trilha adaptativa →

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