A 34-year-old male with a history of intravenous drug use presents to the emergency department with a 2-week history of fever, night sweats, and progressive dyspnea. On examination, temperature is 38.9°C, heart rate is 112 bpm, and respiratory rate is 22/min. Cardiac auscultation reveals a holosystolic murmur best heard at the left lower sternal border that increases in intensity with inspiration. Laboratory studies show a positive blood culture for methicillin-sensitive Staphylococcus aureus. Transthoracic echocardiography demonstrates a large, mobile vegetation adherent to the tricuspid valve with severe tricuspid regurgitation. Which of the following best explains the cardiac findings in this patient?

1. A)Mitral regurgitation from endocarditis with septic embolization to the coronary arteries
2. B)Acute aortic regurgitation secondary to septic aortic root abscess
3. C)Tricuspid regurgitation from infective endocarditis with vegetative destruction of valve leafletsGABARITO
4. D)Pulmonary regurgitation from acute pulmonary hypertension secondary to recurrent septic pulmonary emboli
5. E)Functional tricuspid regurgitation from right ventricular dilation due to acute cor pulmonale