A 70-year-old man with small cell lung carcinoma presents with headache and confusion. Vital signs show BP 128/76 mmHg, HR 82/min, RR 16/min, temperature 37.2°C. Laboratory studies reveal serum sodium 118 mEq/L, serum osmolality 245 mOsm/kg, and urine osmolality 580 mOsm/kg (inappropriately concentrated). Chest imaging confirms SCLC. He denies recent diuretic use. A selective V2 receptor antagonist is initiated for chronic symptomatic SIADH. Which medication was most likely prescribed?
- A)TolvaptanGABARITO
- B)Oxytocin
- C)Fludrocortisone
- D)Demeclocycline
- E)Desmopressin
Explicação
Tolvaptan selectively blocks V2 receptors and is used for euvolemic hyponatremia due to SIADH. By preventing ADH mediated water reabsorption in the collecting duct, it increases free water excretion and raises serum sodium. Ver explicação completa e trilha adaptativa →