A 65-year-old man with recurrent ventricular tachycardia was started on antiarrhythmic therapy. Three months later, he presents with progressive dyspnea, orthopnea, and fatigue. Vital signs show BP 128/82, HR 88, RR 22, SpO2 89% on room air. Chest X-ray reveals bilateral interstitial infiltrates. Laboratory studies show TSH 8.2 mIU/L (elevated), normal ejection fraction on echocardiography, and negative antinuclear antibody. Which antiarrhythmic drug is the most likely cause of these findings?
- A)Verapamil
- B)Digoxin
- C)Metoprolol
- D)AmiodaroneGABARITO
- E)Adenosine
Explicação
Amiodarone is correct. This class III antiarrhythmic can cause pulmonary fibrosis, thyroid dysfunction, hepatotoxicity, corneal deposits, and skin discoloration. Its broad electrophysiologic activity makes it effective for both atrial and ventricular arrhythmi... Ver explicação completa e trilha adaptativa →