A 52-year-old man presents with progressive fatigue, arthralgias, and skin hyperpigmentation. Vital signs show BP 128/82, HR 88, RR 16, temperature 37°C, SpO2 98%. Laboratory studies reveal serum ferritin 850 ng/mL, transferrin saturation 92%, and elevated transaminases. Abdominal ultrasound demonstrates hepatomegaly with cirrhotic features. He denies abdominal pain or jaundice. Which organ system manifestation is most likely if this disease progresses untreated?
- A)Lead pipe colon from mucosal inflammation
- B)Pruritus from autoimmune destruction of intrahepatic bile ducts
- C)Restrictive or dilated cardiomyopathyGABARITO
- D)Copper deposition in the basal ganglia
- E)Flushing and wheezing from serotonin excess
Explicação
Hereditary hemochromatosis causes iron deposition in multiple organs, classically producing cirrhosis, diabetes, skin bronzing, hypogonadism, and cardiomyopathy. The combination of hyperpigmentation, endocrine dysfunction, and iron studies strongly supports th... Ver explicação completa e trilha adaptativa →