A 45-year-old woman undergoes a liver biopsy for suspected cirrhosis. Microscopic examination reveals extensive fibrosis with bridging between portal tracts and central veins, along with regenerative nodules of hepatocytes. The pathologist notes activation of hepatic stellate cells with increased collagen deposition in the space of Disse. Which of the following histological features best explains the mechanism of hepatic fibrosis in this patient?
- A)Increased synthesis of type IV collagen by portal tract bile duct epithelium
- B)Transformation of hepatic stellate cells into myofibroblasts with increased type I and III collagen synthesisGABARITO
- C)Proliferation of hepatocytes leading to compression of the sinusoidal endothelium
- D)Metaplasia of hepatic sinusoidal endothelial cells into fibroblasts
- E)Accumulation of lipid-laden Kupffer cells within the space of Disse
Explicação
Hepatic stellate cells (located in the space of Disse) are the primary source of extracellular matrix in liver fibrosis. Upon chronic liver injury, these cells undergo activation and transformation into myofibroblasts, which proliferate and synthesize excessiv... Ver explicação completa e trilha adaptativa →