A 9-year-old boy from equatorial Africa presents with a rapidly enlarging jaw mass and fever. Vital signs show temperature 38.5°C, HR 110/min, BP 105/68 mmHg, RR 22/min, SpO2 98% on room air. CBC reveals WBC 18,000/μL with 85% blasts. Jaw biopsy demonstrates sheets of medium-sized lymphoid cells with numerous tangible body macrophages creating a starry-sky appearance. He denies abdominal pain. Which genetic abnormality is most likely present?
- A)t(14;18) causing BCL2 overexpression
- B)t(15;17) causing PML-RARA fusion
- C)t(9;22) causing BCR-ABL fusion
- D)t(11;14) causing cyclin D1 overexpression
- E)t(8;14) causing c-MYC activationGABARITO
Explicação
Burkitt lymphoma is the correct answer because the endemic African form often presents as a jaw mass with classic starry-sky morphology driven by c-MYC activation through t(8;14). Ver explicação completa e trilha adaptativa →