A 68-year-old man presents with a 3-year history of progressive difficulty initiating movement, muscle rigidity, and a resting tremor that disappears with action. He walks with small, shuffling steps and has reduced facial expressiveness. Dopamine D2 receptor binding is significantly reduced in the striatum on PET imaging. Which of the following is the most likely diagnosis?
- A)Essential tremor
- B)Progressive supranuclear palsy
- C)Parkinson diseaseGABARITO
- D)Wilson disease
- E)Huntington disease
Explicação
The clinical triad of bradykinesia, rigidity, and resting tremor plus reduced striatal dopamine on PET is pathognomonic for Parkinson disease, a neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra. Ver explicação completa e trilha adaptativa →