A 2-day-old male presents with cyanosis, tachypnea (RR 58/min), and poor feeding. Vital signs show HR 165/min, BP 62/38 mmHg, SpO2 78% on room air, and temperature 37.2°C. He has hepatomegaly but no murmur. Chest X-ray demonstrates cardiomegaly with increased pulmonary vascular markings. Echocardiography reveals a single arterial trunk arising from the heart with a large ventricular septal defect. Which embryologic mechanism best explains this presentation?
- A)Failure of the aorticopulmonary septum to formGABARITO
- B)Premature closure of the ductus arteriosus
- C)Underdevelopment of the left fourth aortic arch
- D)Failure of the tricuspid valve to canalize
- E)Failure of the septum primum to close the foramen ovale
Explicação
Persistent truncus arteriosus results from failure of neural crest derived truncal ridges to form the aorticopulmonary septum. A single outflow tract persists and is commonly associated with a ventricular septal defect. The lesion causes mixing of oxygenated a... Ver explicação completa e trilha adaptativa →