A 71-year-old woman with Parkinson disease treated with levodopa for 8 years presents with repetitive involuntary writhing and choreiform movements beginning 30 minutes after each dose. Vital signs: BP 138/82, HR 92, RR 16, Temp 37°C, SpO2 98%. Brain MRI shows no structural abnormalities. Her bradykinesia improves with medication, but tremor persists. She denies hallucinations. Which of the following best explains these new involuntary movements?
- A)Progression to Huntington disease
- B)Acute dystonic reaction from dopamine antagonism
- C)Essential tremor unmasked by beta-blocker withdrawal
- D)Levodopa-induced dyskinesia from pulsatile dopaminergic stimulationGABARITO
- E)Cerebellar degeneration from alcohol use
Explicação
Long-term levodopa therapy can produce peak-dose dyskinesias due to fluctuating dopaminergic stimulation. Ver explicação completa e trilha adaptativa →