A 46-year-old woman presents with 3 months of progressive proximal muscle weakness affecting stair climbing and hair combing. Vital signs: BP 128/82, HR 92, RR 16, Temp 37°C, SpO2 98%. Physical examination reveals no skin rash. Serum creatine kinase is markedly elevated at 3,200 U/L. Electromyography shows myopathic pattern. Muscle biopsy is most likely to show which of the following findings?
- A)Neurogenic grouped atrophy from denervation
- B)Dystrophin deficiency in muscle fibers
- C)Amyloid deposition in endoneurial tissue
- D)Endomysial inflammation with CD8 positive T cellsGABARITO
- E)Perimysial inflammation with perifascicular atrophy
Explicação
Polymyositis is an inflammatory myopathy characterized by proximal muscle weakness, elevated CK, and endomysial inflammation driven largely by CD8 positive cytotoxic T cells. Lack of rash helps distinguish it from dermatomyositis. Ver explicação completa e trilha adaptativa →