A 17-year-old boy develops rapidly increasing core temperature (40.2°C), generalized muscle rigidity, and tachycardia (HR 142/min) shortly after induction of general anesthesia with succinylcholine and sevoflurane. His blood pressure is 156/94 mmHg, respiratory rate 28/min, and arterial blood gas shows hypercapnia (PaCO2 68 mmHg) with metabolic acidosis. Serum creatinine kinase is markedly elevated at 8,500 U/L. He has no known prior anesthetic complications. Which of the following is the most appropriate treatment?
- A)Cyproheptadine
- B)DantroleneGABARITO
- C)Naloxone
- D)Atropine
- E)Bromocriptine
Explicação
Malignant hyperthermia is due to uncontrolled calcium release from the sarcoplasmic reticulum, usually from an inherited ryanodine receptor defect. Dantrolene inhibits calcium release and is the specific treatment. Ver explicação completa e trilha adaptativa →