A 72-year-old man presents with progressive nocturia (×4 per night) and a diminished urinary stream over 3 years. He reports incomplete emptying but denies dysuria, hematuria, or fever. Vital signs are normal. Digital rectal examination reveals a uniformly enlarged, firm prostate without nodules. Serum PSA is 2.1 ng/mL. Transurethral resection of prostate (TURP) is performed for obstructive symptoms. Histologic examination of the resected tissue shows nodular hyperplasia with interspersed fibrous septa. Which tissue component is primarily responsible for the obstructive pathology in benign prostatic hyperplasia?
- A)Hyperplasia of acinar and ductal glandular epithelium with preserved columnar morphology
- B)Benign adenocarcinoma arising from transition zone glands
- C)Nodular hyperplasia of smooth muscle and fibrous stromal tissueGABARITO
- D)Squamous metaplasia of the urethral mucosa with keratinization
- E)Lymphoid follicle formation with germinal centers compressing the urethra
Explicação
Benign prostatic hyperplasia is fundamentally characterized by nodular hyperplasia of the transition zone, with the predominant pathologic component being smooth muscle and fibrous stromal proliferation rather than glandular epithelium. The smooth muscle and s... Ver explicação completa e trilha adaptativa →