A 58-year-old man with history of smoking presents with acute chest pain, diaphoresis, and dyspnea. Vital signs show BP 142/88 mmHg, HR 102 bpm, RR 18, temp 37.2°C, SpO2 98% on room air. ECG demonstrates ST-elevation in leads II, III, aVF. Troponin I is elevated at 8.2 ng/mL. Two weeks post-MI, echocardiography reveals a noncontractile fibrous scar in the inferior wall without ventricular rupture. Which mediator most strongly promotes fibroblast chemotaxis and collagen deposition during cardiac wound repair?
- A)C3a
- B)Nitric oxide
- C)Transforming growth factor betaGABARITO
- D)IL 8
- E)Histamine
Explicação
TGF beta is one of the most important profibrotic cytokines in healing, stimulating fibroblast migration, collagen synthesis, and inhibition of matrix degradation. Following myocardial infarction, it contributes to scar formation that replaces necrotic myocard... Ver explicação completa e trilha adaptativa →