A 52-year-old woman presents with rapidly progressive renal failure and hematuria. Vital signs show BP 158/92 mmHg, HR 98/min, RR 20/min, Temp 37.2°C, SpO2 98% on room air. Serum creatinine is 4.2 mg/dL with RBC casts on urinalysis. She reports recurrent sinusitis and persistent cough but denies hemoptysis. Kidney biopsy demonstrates crescentic glomerulonephritis with minimal immune deposition on immunofluorescence. Which antibody is most likely present?
- A)c ANCA directed against proteinase 3GABARITO
- B)Anti phospholipase A2 receptor antibodies
- C)Anti mitochondrial antibodies
- D)Anti double stranded DNA antibodies
- E)Anti glomerular basement membrane antibodies
Explicação
Pauci immune crescentic glomerulonephritis with upper and lower respiratory tract involvement suggests granulomatosis with polyangiitis, which is associated with c ANCA directed against proteinase 3. The renal lesion is a rapidly progressive nephritic syndrome... Ver explicação completa e trilha adaptativa →