A 33 year old man with untreated HIV presents with worsening edema and frothy urine. Laboratory studies show hypoalbuminemia and heavy proteinuria. Kidney biopsy demonstrates sclerosis involving some but not all glomeruli and affecting only portions of the involved glomeruli. Which of the following best describes the mechanism of this disease?
- A)Podocyte injury with nonselective protein lossGABARITO
- B)Immune complex deposition after streptococcal infection
- C)Deposition of misfolded transthyretin in glomeruli
- D)Antibody mediated attack on basement membrane collagen
- E)Mesangial deposition of IgA following mucosal infection
Explicação
Focal segmental glomerulosclerosis is a nephrotic syndrome associated with HIV, heroin use, obesity, and reduced nephron mass. It reflects podocyte injury and produces nonselective proteinuria, and it often progresses to chronic kidney disease with poor steroi... Ver explicação completa e trilha adaptativa →