A 34 year old man who works processing imported animal hides presents with fever, dyspnea, and chest discomfort. Chest radiograph shows a widened mediastinum and pleural effusions. Blood cultures grow large gram positive spore forming rods. Which of the following virulence mechanisms is most directly responsible for the marked edema seen with this infection?
- A)Inactivation of elongation factor 2
- B)Inhibition of acetylcholine release at the neuromuscular junction
- C)Cleavage of synaptobrevin in inhibitory neurons
- D)Superantigen mediated T cell activation
- E)Adenylate cyclase mediated increase in cyclic AMPGABARITO
Explicação
Adenylate cyclase mediated increase in cyclic AMP is correct. Bacillus anthracis edema factor is a calmodulin dependent adenylate cyclase that increases intracellular cyclic AMP and causes severe edema. The occupational exposure and widened mediastinum indicat... Ver explicação completa e trilha adaptativa →