A 24-year-old woman presents with a 6-month history of chronic diarrhea, bloating, and progressive fatigue. Vital signs show BP 118/76 mmHg, HR 88/min, RR 16/min, and temperature 37.2°C. She has a pruritic vesicular rash on extensor elbows. Laboratory studies reveal hemoglobin 10.2 g/dL and iron deficiency anemia. Small-bowel biopsy demonstrates villous atrophy, crypt hyperplasia, and increased intraepithelial lymphocytes. Serologic testing for IgA antibodies against tissue transglutaminase is pending. Which antibody is most likely positive?
- A)ASCA
- B)IgA anti-tissue transglutaminaseGABARITO
- C)p-ANCA
- D)Anti-smooth muscle antibody
- E)Anti-mitochondrial antibody
Explicação
Celiac disease is an immune-mediated enteropathy triggered by gliadin in genetically susceptible patients and is associated with dermatitis herpetiformis and iron deficiency anemia. IgA anti-tissue transglutaminase is a high yield screening antibody, and biops... Ver explicação completa e trilha adaptativa →