A 3-day-old newborn presents with cyanosis and severe respiratory distress. Vital signs show HR 168 bpm, RR 52/min, BP 55/32 mmHg, SpO2 78% on room air, and temperature 37.2°C. Echocardiography demonstrates complete transposition of the great arteries with the aorta arising anteriorly from the right ventricle and the pulmonary artery from the left ventricle. Chest X-ray shows an "egg-on-string" appearance. There is no evidence of septal defects. Which embryologic process is most likely disrupted?
- A)Incomplete resorption of septum primum
- B)Premature closure of foramen ovale
- C)Abnormal truncus arteriosus septationGABARITO
- D)Defective endocardial cushion development
- E)Failure of neural crest cell migration
Explicação
Transposition of the great arteries results from abnormal division and rotation of the truncus arteriosus by the aorticopulmonary septum during weeks 4-6 of development. Improper spiraling of this septum causes the vessels to switch their normal connections to... Ver explicação completa e trilha adaptativa →