A 17-year-old boy presents with mucosal neuromas on his lips and tongue, marfanoid habitus, and chronic constipation. Vital signs are BP 155/92 mmHg, HR 98 bpm, RR 16, Temp 37°C, SpO2 98%. Physical examination reveals medullary thyroid carcinoma on imaging. Plasma metanephrine levels are elevated at 285 pg/mL (normal <90). He denies headaches or diaphoresis. Which additional malignancy carries the highest risk in this patient?
- A)Pancreatic insulinoma
- B)PheochromocytomaGABARITO
- C)Parathyroid adenoma
- D)Parathyroid carcinoma
- E)Pituitary prolactinoma
Explicação
MEN 2B is a RET associated syndrome characterized by medullary thyroid carcinoma, pheochromocytoma, mucosal neuromas, and marfanoid habitus. Unlike MEN 2A, parathyroid disease is not a prominent feature. The mucosal neuromas make this diagnosis especially dist... Ver explicação completa e trilha adaptativa →