A 27-year-old man presents with hemoptysis and cola-colored urine. Vital signs show BP 148/92 mmHg, HR 102/min, RR 20/min, SpO2 94% on room air. Chest imaging reveals diffuse alveolar infiltrates. Urinalysis shows dysmorphic RBCs with RBC casts; proteinuria is 1.2 g/24 hours. Serum creatinine is 2.1 mg/dL. He denies recent infections. Which immunofluorescence pattern on kidney biopsy is most likely?
- A)No immune deposits on immunofluorescence
- B)Linear IgG deposition along the glomerular basement membraneGABARITO
- C)Subepithelial granular immune deposits
- D)Congo red-positive fibrils
- E)Granular mesangial IgA deposition
Explicação
Goodpasture syndrome is caused by antibodies against the alpha-3 chain of type IV collagen in glomerular and alveolar basement membranes. The classic biopsy finding is linear IgG deposition along the glomerular basement membrane with pulmonary hemorrhage and r... Ver explicação completa e trilha adaptativa →