A 59-year-old woman presents with right upper quadrant pain, weight loss, and jaundice. Vital signs show BP 128/82, HR 92, RR 16, Temp 37.2°C, SpO2 98%. CT abdomen reveals a 4-cm heterogeneous liver mass with elevated transaminases (AST 187 U/L). Liver biopsy demonstrates nests of atypical epithelial cells without lymphoid aggregates. Which immunohistochemical stain would best differentiate carcinoma from sarcoma or lymphoma in this metastatic malignancy of unknown primary?
- A)Glial fibrillary acidic protein
- B)CytokeratinGABARITO
- C)Desmin
- D)CD31
- E)Vimentin
Explicação
Cytokeratins are intermediate filaments expressed in epithelial cells and are commonly used to identify carcinomas. Positive cytokeratin staining supports epithelial origin in a metastatic tumor. Ver explicação completa e trilha adaptativa →