A 62-year-old woman with metastatic breast cancer comes to the physician because of a 2-day history of fever, chills, and new gluteal lesions. The lesions began as painless red macules and evolved into painful ulcers overnight. She received her fourth course of palliative chemotherapy 2 weeks ago. Her temperature is 38.2°C (100.8°F). Laboratory studies show a leukocyte count of 2,000/mm³ (20% segmented neutrophils). A photograph of one of the skin lesions is shown. Which of the following virulence factors is most likely involved in the pathogenesis of this patient's skin finding?
- A)Edema toxin
- B)Heat-stable toxin
- C)Toxic shock syndrome toxin-1
- D)Exotoxin AGABARITO
- E)Alpha toxin
Explicação
Exotoxin A is an AB toxin produced by Pseudomonas aeruginosa that inhibits protein synthesis by inactivating elongation factor 2 (EF-2) via ADP-ribosylation. This leads to cell death, which is responsible for the tissue necrosis seen in ecthyma gangrenosum. Th... Ver explicação completa e trilha adaptativa →