A 46-year-old man presents with progressive exertional chest pain. Vital signs show BP 158/94 mmHg, HR 92/min, RR 16/min, SpO2 98% on room air. Physical examination reveals yellow plaques over elbows and palmar creases. Fasting lipid panel demonstrates total cholesterol 520 mg/dL and triglycerides 680 mg/dL; LDL 380 mg/dL. EKG shows no acute ischemic changes. He denies statin use. Accumulation of which particles most likely causes this disorder?
- A)Lipoprotein(a) only
- B)Chylomicron and VLDL remnantsGABARITO
- C)LDL particles only
- D)Chylomicrons only
- E)HDL particles
Explicação
Familial dysbetalipoproteinemia is usually due to defective apolipoprotein E, causing impaired hepatic clearance of chylomicron and VLDL remnants. Patients can develop mixed hyperlipidemia, premature atherosclerosis, and palmar or tuberous xanthomas. The palma... Ver explicação completa e trilha adaptativa →