A 35-year-old woman presents with medullary thyroid carcinoma discovered on biopsy. Her brother underwent adrenalectomy for pheochromocytoma (plasma metanephrines elevated at 450 pg/mL), and her mother has primary hyperparathyroidism with serum calcium of 11.2 mg/dL. The patient's blood pressure is 148/92 mmHg with heart rate of 92 bpm. Physical examination reveals no cutaneous manifestations. Which syndrome best explains this familial clustering of endocrine neoplasias?
- A)Von Hippel Lindau syndrome
- B)MEN 2B
- C)MEN 1
- D)Carney complex
- E)MEN 2AGABARITO
Explicação
MEN 2A is caused by activating RET mutations and includes medullary thyroid carcinoma, pheochromocytoma, and parathyroid hyperplasia. Ver explicação completa e trilha adaptativa →