A 35-year-old woman presents with medullary thyroid carcinoma discovered on biopsy. Her brother underwent adrenalectomy for pheochromocytoma (plasma metanephrines elevated at 450 pg/mL), and her mother has primary hyperparathyroidism with serum calcium of 11.2 mg/dL. The patient's blood pressure is 148/92 mmHg with heart rate of 92 bpm. Physical examination reveals no cutaneous manifestations. Which syndrome best explains this familial clustering of endocrine neoplasias?

  1. A)Von Hippel Lindau syndrome
  2. B)MEN 2B
  3. C)MEN 1
  4. D)Carney complex
  5. E)MEN 2AGABARITO

Explicação

MEN 2A is caused by activating RET mutations and includes medullary thyroid carcinoma, pheochromocytoma, and parathyroid hyperplasia. Ver explicação completa e trilha adaptativa →

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