A 37-year-old woman presents 18 hours after consuming improperly canned vegetables with blurred vision, dysphagia, and progressive descending symmetric paralysis. Vital signs: BP 138/82, HR 98, RR 16, Temperature 37.2°C, SpO2 98% on room air. Examination reveals fixed dilated pupils and facial weakness. Serum electrolytes are normal. She denies recent antibiotic use. Which of the following best explains this clinical presentation?
- A)Antibody mediated destruction of nicotinic receptors
- B)Neuronal degeneration in the substantia nigra
- C)Toxin mediated inhibition of glycine release in the spinal cord
- D)Antibody mediated demyelination of peripheral nerves
- E)Toxin mediated inhibition of acetylcholine release at peripheral cholinergic synapsesGABARITO
Explicação
Foodborne botulism causes cranial nerve symptoms followed by descending flaccid paralysis and autonomic dysfunction. The toxin blocks acetylcholine release at cholinergic nerve terminals by cleaving SNARE proteins. Ver explicação completa e trilha adaptativa →