A 28-year-old woman with recurrent pancreatitis presents with vital signs BP 118/76, HR 88, RR 16, Temp 37.2°C, SpO2 98%. Fasting serum triglycerides measure 2200 mg/dL with visibly milky plasma. Fasting glucose and insulin are normal. Abdominal ultrasound shows no acute inflammation. Genetic testing confirms lipoprotein lipase gene mutations. She takes no lipid-lowering medications. Which lipoprotein accumulates most in her circulation?
- A)HDL complexes
- B)ChylomicronsGABARITO
- C)Lipoprotein(a)
- D)LDL particles
- E)VLDL remnants
Explicação
Lipoprotein lipase (LPL) hydrolyzes triglycerides in chylomicrons and VLDL. LPL deficiency prevents chylomicron clearance, causing severe hypertriglyceridemia with massive chylomicron accumulation and eruptive xanthomas and pancreatitis. Ver explicação completa e trilha adaptativa →