A 45-year-old researcher is purifying lysosomal proteins from cultured hepatocytes for functional studies. He uses affinity chromatography with a column matrix conjugated to an antibody. His goal is to isolate proteins destined for lysosomal trafficking. Serum albumin levels are normal, and electron microscopy confirms intact lysosomal structures. He has not used protease inhibitors in his buffer. Which antibody targeting the following modification would most effectively purify lysosomal-destined proteins?

1. A)Clathrin
2. B)Sialic acid
3. C)Acid hydrolases
4. D)Glucose-6-phosphate
5. E)Mannose-6-phosphateGABARITO