A 5 year old boy is brought to the emergency department because of decreased urine output and lethargy 5 days after an episode of bloody diarrhea from undercooked beef. He is pale and has scattered petechiae. Laboratory studies show thrombocytopenia, elevated creatinine, elevated LDH, and schistocytes on blood smear. Which of the following mechanisms most likely triggered his illness?
- A)Loss of factor V activity
- B)Protein C deficiency
- C)Shiga toxin mediated endothelial damageGABARITO
- D)ADAMTS13 autoantibody
- E)Complement factor C5 deficiency
Explicação
Typical hemolytic uremic syndrome follows infection with enterohemorrhagic Escherichia coli producing Shiga like toxin. The toxin damages endothelial cells, especially in the kidney, leading to platelet activation, microthrombi, thrombocytopenia, and microangi... Ver explicação completa e trilha adaptativa →