A 69 year old man is brought by his wife because of progressive slowing of movement and a tremor in his right hand at rest. He has difficulty initiating gait and his handwriting has become very small. Examination shows cogwheel rigidity, bradykinesia, and a masked facial expression. Loss of neurons in which structure most likely underlies this condition?
- A)Locus coeruleus
- B)Caudate nucleus
- C)Substantia nigra pars compactaGABARITO
- D)Cerebellar vermis
- E)Subthalamic nucleus
Explicação
Substantia nigra pars compacta is correct. Parkinson disease results from degeneration of dopaminergic neurons projecting to the striatum, leading to decreased direct pathway activity and increased indirect pathway activity. This produces bradykinesia, resting... Ver explicação completa e trilha adaptativa →