A 7-year-old boy from Ghana presents with nodules on his shins, back, and elbows. He also complains of nerve pain along his forearms. Examination reveals areas of decreased sensation over his arms and legs. Nerve biopsy reveals acid-fast bacilli. Which of the following best describes the immunological basis for his cutaneous manifestations?
- A)Type I hypersensitivity with mast cell activation
- B)Type III hypersensitivity with immune complex deposition
- C)Complement-mediated alternative pathway activation
- D)Type II hypersensitivity with antibody-mediated cytotoxicity
- E)Type IV hypersensitivity reaction with granuloma formationGABARITO
Explicação
This child has leprosy (Hansen disease) caused by Mycobacterium leprae. The nodular lesions represent tuberculoid leprosy with Type IV hypersensitivity granulomatous response. Patients with tuberculoid disease mount a strong Th1 cell-mediated immune response, ... Ver explicação completa e trilha adaptativa →