An investigator is studying the immunologic response to a Staphylococcus aureus toxin in a mouse model. Fourteen days after injecting mice with this toxin, he isolates antibodies against neutrophil proteinase 3 in their serum. A patient with high concentrations of these antibodies would most likely present with which of the following clinical features?
- A)Polyneuropathy and melena
- B)Asthma attacks and allergic sinusitis
- C)Visual impairment and jaw claudication
- D)Nasal mucosal ulcerations and hematuriaGABARITO
- E)Migratory thrombophlebitis and digital ulcers
Explicação
Nasal mucosal ulcerations and hematuria (due to underlying rapidly progressive glomerulonephritis) are features of granulomatosis with polyangiitis (GPA). Anti-proteinase 3 antibodies (PR3-ANCA/c-ANCA) show a diffuse cytoplasmic staining pattern on immunofluor... Ver explicação completa e trilha adaptativa →