A 25-year-old woman taking sertraline 100 mg daily develops agitation, diaphoresis, and diarrhea shortly after starting linezolid for pneumonia. Vital signs show BP 148/92, HR 118, RR 22, temperature 39.2°C, SpO2 98% on room air. Physical examination reveals hyperreflexia and inducible clonus. Laboratory studies show creatine kinase elevated at 1,200 U/L. There is no recent cocaine use. Which of the following is the most likely diagnosis?
- A)Neuroleptic malignant syndrome
- B)Anticholinergic poisoning
- C)Serotonin syndromeGABARITO
- D)Malignant hyperthermia
- E)Sympathomimetic intoxication only
Explicação
Serotonin syndrome is caused by excess serotonergic activity and classically features mental status changes, autonomic instability, hyperreflexia, and clonus. Combining an SSRI with linezolid, which has MAOI activity, is a classic trigger. Ver explicação completa e trilha adaptativa →