A 45-year-old woman presents with progressive proximal muscle weakness, purple striae, central obesity, and hypertension. Laboratory studies show elevated 24-hour urinary free cortisol and a plasma cortisol of 8 μg/dL at 8 AM. The low-dose dexamethasone suppression test shows cortisol of 18 μg/dL. Which of the following is the most likely diagnosis?
- A)Adrenal insufficiency
- B)Primary hyperaldosteronism
- C)Cushing syndromeGABARITO
- D)Thyroiditis
- E)Pheochromocytoma
Explicação
This patient has classic Cushing syndrome with truncal obesity, proximal weakness, purple striae, and hypertension. The elevated 24-hour urinary free cortisol and loss of normal diurnal variation (8 AM cortisol >5 μg/dL) are diagnostic. Failure of suppression ... Ver explicação completa e trilha adaptativa →